Coach: Doug Kay (8-8)
StatisticsRoster
The of the ended the season with a record of wins and losses, Doug Kay coached the team.
Regular Season Points For: 724
Regular Season Points Against: 717
| Date | Game | Res | Home | Road | Record | ||
| January 29, 2006 | Grand Rapids Rampage 30 at Columbus Destroyers 53 | W | 1-0-0 | 0-0-0 | 1-0-0 | ||
| February 3, 2006 | Columbus Destroyers 27 at Nashville Kats 53 | L | 1-0-0 | 0-1-0 | 1-1-0 | ||
| February 11, 2006 | Dallas Desperados 52 at Columbus Destroyers 38 | L | 1-1-0 | 0-1-0 | 1-2-0 | ||
| February 19, 2006 | Columbus Destroyers 24 at Kansas City Brigade 45 | L | 1-1-0 | 0-2-0 | 1-3-0 | ||
| February 24, 2006 | Arizona Rattlers 26 at Columbus Destroyers 42 | W | 2-1-0 | 0-2-0 | 2-3-0 | ||
| March 3, 2006 | Columbus Destroyers 65 at New York Dragons 54 | W | 2-1-0 | 1-2-0 | 3-3-0 | ||
| March 10, 2006 | Georgia Force 68 at Columbus Destroyers 50 | L | 2-2-0 | 1-2-0 | 3-4-0 | ||
| March 18, 2006 | Philadelphia Soul 20 at Columbus Destroyers 53 | W | 3-2-0 | 1-2-0 | 4-4-0 | ||
| March 25, 2006 | Columbus Destroyers 65 at Colorado Crush 21 | W | 3-2-0 | 2-2-0 | 5-4-0 | ||
| April 1, 2006 | Columbus Destroyers 30 at Dallas Desperados 51 | L | 3-2-0 | 2-3-0 | 5-5-0 | ||
| April 9, 2006 | Orlando Predators 39 at Columbus Destroyers 36 | L | 3-3-0 | 2-3-0 | 5-6-0 | ||
| April 14, 2006 | New York Dragons 64 at Columbus Destroyers 57 | L | 3-4-0 | 2-3-0 | 5-7-0 | ||
| April 21, 2006 | Columbus Destroyers 46 at Philadelphia Soul 45 | W | 3-4-0 | 3-3-0 | 6-7-0 | ||
| April 29, 2006 | Columbus Destroyers 40 at Austin Wranglers 33 | W | 3-4-0 | 4-3-0 | 7-7-0 | ||
| May 6, 2006 | Tampa Bay Storm 48 at Columbus Destroyers 51 | W | 4-4-0 | 4-3-0 | 8-7-0 | ||
| May 13, 2006 | Columbus Destroyers 47 at San Jose SaberCats 68 | L | 4-4-0 | 4-4-0 | 8-8-0 |