Coach: Tony Dungy (14-2)
StatisticsRoster
The of the ended the season with a record of wins and losses, Tony Dungy coached the team.
Regular Season Points For: 439
Regular Season Points Against: 247
| Date | Game | Res | Home | Road | Record | ||
| September 11, 2005 | Indianapolis Colts 24 at Baltimore Ravens 7 | W | 0-0-0 | 1-0-0 | 1-0-0 | ||
| September 18, 2005 | Jacksonville Jaguars 3 at Indianapolis Colts 10 | W | 1-0-0 | 1-0-0 | 2-0-0 | ||
| September 25, 2005 | Cleveland Browns 6 at Indianapolis Colts 13 | W | 2-0-0 | 1-0-0 | 3-0-0 | ||
| October 2, 2005 | Indianapolis Colts 31 at Tennessee Titans 10 | W | 2-0-0 | 2-0-0 | 4-0-0 | ||
| October 9, 2005 | Indianapolis Colts 28 at San Francisco 49ers 3 | W | 2-0-0 | 3-0-0 | 5-0-0 | ||
| October 17, 2005 | St. Louis Rams 28 at Indianapolis Colts 45 | W | 3-0-0 | 3-0-0 | 6-0-0 | ||
| October 23, 2005 | Indianapolis Colts 38 at Houston Texans 20 | W | 3-0-0 | 4-0-0 | 7-0-0 | ||
| November 7, 2005 | Indianapolis Colts 40 at New England Patriots 21 | W | 3-0-0 | 5-0-0 | 8-0-0 | ||
| November 13, 2005 | Houston Texans 17 at Indianapolis Colts 31 | W | 4-0-0 | 5-0-0 | 9-0-0 | ||
| November 20, 2005 | Indianapolis Colts 45 at Cincinnati Bengals 37 | W | 4-0-0 | 6-0-0 | 10-0-0 | ||
| November 28, 2005 | Pittsburgh Steelers 7 at Indianapolis Colts 26 | W | 5-0-0 | 6-0-0 | 11-0-0 | ||
| December 4, 2005 | Tennessee Titans 3 at Indianapolis Colts 35 | W | 6-0-0 | 6-0-0 | 12-0-0 | ||
| December 11, 2005 | Indianapolis Colts 26 at Jacksonville Jaguars 18 | W | 6-0-0 | 7-0-0 | 13-0-0 | ||
| December 18, 2005 | San Diego Chargers 26 at Indianapolis Colts 17 | L | 6-1-0 | 7-0-0 | 13-1-0 | ||
| December 24, 2005 | Indianapolis Colts 13 at Seattle Seahawks 28 | L | 6-1-0 | 7-1-0 | 13-2-0 | ||
| January 1, 2006 | Arizona Cardinals 13 at Indianapolis Colts 17 | W | 7-1-0 | 7-1-0 | 14-2-0 | ||
| January 15, 2006 | Pittsburgh Steelers 21 at Indianapolis Colts 18 | L | 0-1-0 | 0-0-0 | 0-1-0 | AFC Divisional Playoff |