Coach: Jack Patera (4-12)
StatisticsRoster
The of the ended the season with a record of wins and losses, Jack Patera coached the team.
Regular Season Points For: 291
Regular Season Points Against: 408
| Date | Game | Res | Home | Road | Record | ||
| September 7, 1980 | San Diego Chargers 34 at Seattle Seahawks 13 | L | 0-1-0 | 0-0-0 | 0-1-0 | ||
| September 14, 1980 | Seattle Seahawks 17 at Kansas City Chiefs 16 | W | 0-1-0 | 1-0-0 | 1-1-0 | ||
| September 21, 1980 | New England Patriots 37 at Seattle Seahawks 31 | L | 0-2-0 | 1-0-0 | 1-2-0 | ||
| September 28, 1980 | Seattle Seahawks 14 at Washington Redskins 0 | W | 0-2-0 | 2-0-0 | 2-2-0 | ||
| October 5, 1980 | Seattle Seahawks 26 at Houston Oilers 7 | W | 0-2-0 | 3-0-0 | 3-2-0 | ||
| October 12, 1980 | Cleveland Browns 27 at Seattle Seahawks 3 | L | 0-3-0 | 3-0-0 | 3-3-0 | ||
| October 19, 1980 | Seattle Seahawks 27 at New York Jets 17 | W | 0-3-0 | 4-0-0 | 4-3-0 | ||
| October 26, 1980 | Seattle Seahawks 14 at Oakland Raiders 33 | L | 0-3-0 | 4-1-0 | 4-4-0 | ||
| November 2, 1980 | Philadelphia Eagles 27 at Seattle Seahawks 20 | L | 0-4-0 | 4-1-0 | 4-5-0 | ||
| November 9, 1980 | Kansas City Chiefs 31 at Seattle Seahawks 30 | L | 0-5-0 | 4-1-0 | 4-6-0 | ||
| November 17, 1980 | Oakland Raiders 19 at Seattle Seahawks 17 | L | 0-6-0 | 4-1-0 | 4-7-0 | ||
| November 23, 1980 | Seattle Seahawks 20 at Denver Broncos 36 | L | 0-6-0 | 4-2-0 | 4-8-0 | ||
| November 27, 1980 | Seattle Seahawks 7 at Dallas Cowboys 51 | L | 0-6-0 | 4-3-0 | 4-9-0 | ||
| December 7, 1980 | New York Giants 27 at Seattle Seahawks 21 | L | 0-7-0 | 4-3-0 | 4-10-0 | ||
| December 13, 1980 | Seattle Seahawks 14 at San Diego Chargers 21 | L | 0-7-0 | 4-4-0 | 4-11-0 | ||
| December 21, 1980 | Denver Broncos 25 at Seattle Seahawks 17 | L | 0-8-0 | 4-4-0 | 4-12-0 |